Table 3.
Coats disease by decade in 351 eyes of 351 patients. Imaging features
| Imaging features | 1973-1979 n=18 eyes in 18 patients (%) | 1980-1989 n=43 eyes in 43 patients (%) | 1990-1999 n=66 eyes in 66 patients (%) | 2000-2009 n=112 eyes in 112 patients (%) | 2010-2018 n=112 eyes in 112 patients (%) | P | Total n=351 eyes in 351 patients (%) |
|---|---|---|---|---|---|---|---|
| Fluorescein angiography* | n=4 | n=17 | n=26 | n=58 | n=87 | n=192 | |
| Telangiectasia | |||||||
| Clock hours Mean (median, range) | 3 (4, 2-4) | 5 (5, 1-12) | 5 (5, 0-12) | 6 (6, 0-12) | 6 (6, 0-12) | 0.38 | 6 (6, 0-12) |
| Most affected region | |||||||
| Temporal | 3 (75) | 12 (71) | 18 (69) | 43 (74) | 69 (79) | 145 (76) | |
| Nasal | 0 (0) | 3 (18) | 2 (8) | 1 (2) | 7 (8) | 13 (7) | |
| Inferior | 1 (25) | 1 (6) | 4 (15) | 9 (16) | 4 (5) | 0.55 | 19 (10) |
| Superior | 0 (0) | 1 (6) | 1 (4) | 3 (5) | 6 (7) | 11 (6) | |
| No telangiectasia | 0 (0) | 0 (0) | 1 (4) | 2 (3) | 1 (1) | 4 (2) | |
| Most affected quadrant | |||||||
| Superonasal | 0 (0) | 1 (6) | 2 (8) | 2 (3) | 6 (7) | 11 (6) | |
| Superotemporal | 1 (25) | 5 (29) | 5 (19) | 20 (34) | 32 (37) | 63 (32) | |
| Inferonasal | 0 (0) | 3 (18) | 5 (19) | 2 (3) | 5 (6) | 0.58 | 15 (8) |
| Inferotemporal | 3 (75) | 8 (47) | 13 (50) | 32 (55) | 43 (49) | 99 (52) | |
| No telangiectasia | 0 (0) | 0 (0) | 1 (3) | 2 (3) | 1 (1) | 4 (2) | |
| Light bulb aneurysms | |||||||
| Clock hours Mean (median, range) | 3 (4, 2-4) | 4 (3, 0-12) | 5 (3, 0-12) | 5 (4, 0-12) | 5 (5, 0-12) | 0.40 | 5 (5, 0-12) |
| Most affected region | |||||||
| Temporal | 3 (75) | 11 (65) | 17 (65) | 41 (71) | 65 (75) | 137 (71) | |
| Nasal | 0 (0) | 3 (18) | 2 (8) | 1 (2) | 5 (6) | 11 (6) | |
| Inferior | 1 (25) | 1 (6) | 4 (15) | 9 (16) | 6 (7) | 0.72 | 21 (11) |
| Superior | 0 (0) | 1 (6) | 1 (4) | 3 (5) | 7 (8) | 12 (6) | |
| No light bulb aneurysms | 0 (0) | 1 (6) | 2 (8) | 4 (7) | 4 (5) | 11 (6) | |
| Most affected quadrant | |||||||
| Superonasal | 1 (25) | 1 (6) | 2 (8) | 1 (2) | 8 (9) | 13 (7) | |
| Superotemporal | 0 (0) | 5 (29) | 6 (23) | 19 (33) | 28 (32) | 48 (22) | |
| Inferonasal | 0 (0) | 3 (18) | 2 (8) | 2 (3) | 3 (3) | 0.53 | 10 (5) |
| Inferotemporal | 3 (75) | 7 (41) | 14 (54) | 32 (55) | 44 (51) | 100 (52) | |
| No light bulb aneurysms | 0 (0) | 1 (6) | 2 (7) | 4 (7) | 4 (5) | 11 (6) | |
| Retinal non-perfusion | |||||||
| Clock hours Mean (median, range) | 4 (5, 2-6) | 4 (3, 0-12) | 3 (3, 0-12) | 5 (4, 0-12) | 6 (6, 0-12) | 0.003 | 5 (5, 0-12) |
| Most affected region | |||||||
| Temporal | 4 (100) | 10 (59) | 14 (54) | 31 (53) | 62 (71) | 121 (63) | |
| Nasal | 0 (0) | 2 (12) | 2 (8) | 1 (2) | 7 (8) | 12 (6) | |
| Inferior | 0 (0) | 0 (0) | 3 (12) | 5 (9) | 5 (6) | 0.23 | 13 (7) |
| Superior | 0 (0) | 1 (6) | 0 (0) | 4 (7) | 4 (5) | 9 (5) | |
| No non-perfusion | 0 (0) | 4 (24) | 7 (27) | 17 (29) | 9 (10) | 37 (19) | |
| Most affected quadrant | |||||||
| Superonasal | 0 (0) | 1 (6) | 2 (8) | 2 (3) | 6 (7) | 11 (6) | |
| Superotemporal | 1 (25) | 5 (29) | 5 (19) | 18 (31) | 29 (33) | 58 (30) | |
| Inferonasal | 0 (0) | 1 (6) | 2 (8) | 1 (2) | 2 (2) | 0.43 | 6 (3) |
| Inferotemporal | 3 (75) | 6 (35) | 10 (38) | 20 (34) | 41 (47) | 80 (42) | |
| No non-perfusion | 0 (0) | 4 (24) | 7 (27) | 17 (29) | 9 (10) | 37 (19) | |
| Other fluorescein features | |||||||
| Cystoid macular edema | 0 (0) | 0 (0) | 2 (8) | 8 (14) | 9 (10) | 0.49 | 19 (10) |
| Neovascularization of the disc | 0 (0) | 0 (0) | 1 (4) | 0 (0) | 1 (1) | 0.59 | 2 (1) |
| Neovascularization of the retina | 0 (0) | 0 (0) | 1 (4) | 2 (3) | 2 (2) | 0.92 | 5 (3) |
| Neovascularization of the iris | 0 (0) | 0 (0) | 1 (4) | 5 (9) | 5 (6) | 0.67 | 11 (3) |
| Optical coherence tomography** | n=0 | n=0 | n=0 | n=41 | n=81 | n=122 | |
| Cystoid macular edema | NA | NA | NA | 17 (42) | 21 (26) | 0.13 | 38 (31) |
| Epiretinal membrane | NA | NA | NA | 13 (32) | 17 (21) | 0.27 | 30 (24) |
| Vitreomacular traction | NA | NA | NA | 4 (10) | 6 (7) | 0.73 | 10 (8) |
| Subretinal fluid | NA | NA | NA | 22 (54) | 38 (47) | 0.71 | 60 (49) |
| Subretinal exudation | NA | NA | NA | 36 (88) | 59 (73) | 0.18 | 95 (78) |
| Intraretinal exudation | NA | NA | NA | 10 (24) | 20 (25) | 0.82 | 30 (25) |
| Central macular thickness (um) | NA | NA | NA | 349 (313, 176-647) | 363 (343, 191-692) | 0.46 | 358 (336, 176-692) |
| Mean (median, range) | |||||||
| Foveal center to RPE thickness (um) | NA | NA | NA | 358 (279, 213-992) | 351 (301, 0-956) | 0.90 | 352 (200, 0-992) |
| Mean (median, range) | |||||||
| Foveal center to base of retina (um) | NA | NA | NA | 255 (247, 188-342) | 302 (251, 0-918) | 0.38 | 293 (252, 0-918) |
| Mean (median, range) | |||||||
| Subfoveal choroid thickness (um) | NA | NA | NA | 207 (211, 96-288) | 294 (295, 0-630) | 0.01 | 279 (282, 0-630) |
| Mean (median, range) | |||||||
| Ultrasonography† | n=5 | n=18 | n=28 | n=83 | n=82 | n=216 | |
| Retinal detachment | 3 (60) | 15 (83) | 23 (82) | 49 (59) | 39 (48) | 0.01 | 129 (60) |
| Partial retinal detachment | 0 (0) | 0 (0) | 2 (7) | 9 (11) | 6 (7) | 0.69 | 17 (8) |
| Total retinal detachment | 1 (20) | 1 (6) | 2 (7) | 6 (7) | 11 (13) | 0.55 | 21 (10) |
| Open funnel detachment | 2 (40) | 8 (44) | 17 (61) | 28 (28) | 15 (18) | 0.001 | 70 (32) |
| Closed funnel detachment | 0 (0) | 6 (33) | 2 (7) | 6 (7) | 7 (9) | 0.01 | 21 (10) |
| Subretinal fluid elevation (mm) | 5 (2, 0-19) | 12 (16, 0-19) | 5 (4, 0-16) | 5 (2, 0-19) | 4 (0, 0-18) | <0.001 | 5 (2, 0-19) |
| Mean (median, range) | |||||||
| Subretinal exudation | 5 (100) | 17 (94) | 27 (96) | 77 (93) | 69 (84) | 0.19 | 195 (90) |
Bold values indicate significant P. *Fluorescein angiography available in 201 eyes **Optical coherence tomography available in 122 eyes †Ultrasonography available in 225 eyes Abbreviations: NA=not applicable Non-perfusion clock hours on fluorescein angiography: Post-hoc analysis (Bonferroni test) showed a significant difference between groups 3 and 5 (P=0.01). There was no significant difference between the means of any other groups (P>0.05). Subretinal fluid elevation (mm) on ultrasound: Post-hoc analysis (Bonferroni test) showed significant differences between groups 2 and 3 (P=0.001), groups 2 and 4 (P<0.001), and groups 2 and 5 (P<0.001). There was no significant difference between the means of any other groups (P>0.05)