Table 4.
Coats disease by decade in 351 eyes of 351 patients. Treatment features
| Treatment features | 1973-1979 n=18 eyes in 18 patients (%) | 1980-1989 n=43 eyes in 43 patients (%) | 1990-1999 n=66 eyes in 66 patients (%) | 2000-2009 n=112 eyes in 112 patients (%) | 2010-2018 n=112 eyes in 112 patients (%) | P | Total n=351 eyes in 351 patients (%) |
|---|---|---|---|---|---|---|---|
| Observation | 7 (39) | 9 (21) | 22 (33) | 23 (21) | 12 (11) | 0.002 | 73 (21) |
| Medical or laser therapy | 9 (50) | 27 (63) | 42 (64) | 84 (75) | 99 (88) | <0.001 | 261 (74) |
| Number of total treatments | 2.9 (2, 1-6) | 2.0 (1, 0-13) | 1.8 (2, 1-4) | 3.6 (3, 1-15) | 4.5 (3, 1-26) | 0.001 | 3.6 (3, 1-26) |
| Mean (median, range) | |||||||
| Argon laser photocoagulation | 5 (55) | 9 (33) | 16 (38) | 45 (40) | 71 (72) | <0.001 | 146 (42) |
| Number of treatments | 2.0 (2, 1-4) | 3.0 (2, 1-11) | 1.2 (1, 1-2) | 1.9 (2, 1-4) | 2.3 (1, 1-20) | 0.22 | 2.1 (1, 1-20) |
| Mean (median, range) | |||||||
| Cryotherapy | 7 (78) | 25 (93) | 30 (71) | 65 (58) | 67 (68) | 0.20 | 194 (55) |
| Number of treatments | 2.3 (2, 1-5) | 2.0 (2, 1-6) | 1.6 (1, 1-3) | 2.3 (2, 1-9) | 2.1 (2, 1-6) | 0.22 | 2.1 (2, 1-9) |
| Mean (median, range) | |||||||
| Sub-Tenon corticosteroid injection | 0 (0) | 1 (4) | 2 (5) | 9 (8) | 29 (29) | <0.001 | 41 (12) |
| Number of treatments | NA | 1.0 (1, 1-1) | 1.0 (1, 1-1) | 1.7 (1, 1-4) | 1.2 (1, 1-3) | 0.24 | 1.3 (1, 1-4) |
| Mean (median, mode) | |||||||
| Intravitreal corticosteroid injection | 0 (0) | 0 (0) | 1 (2) | 4 (4) | 9 (9) | 0.08 | 14 (4) |
| Number of treatments | NA | NA | 1.0 (1, 1-1) | 1.8 (2, 1-3) | 3.7 (1, 1-14) | 0.67 | 2.9 (1, 1-26) |
| Mean (median, range) | |||||||
| Anti-VEGF | 0 (0) | 1 (4) | 1 (2) | 15 (13) | 18 (18) | 0.003 | 35 (10) |
| Number of treatments | NA | 0.1 (0, 0-3) | 1.0 (1, 1-1) | 2.7 (1, 1-12) | 4.2 (2, 1-20) | 0.72 | 3.4 (2, 1-20) |
| Mean (median, range) | |||||||
| Primary enucleation | 2 (11) | 7 (16) | 2 (3) | 5 (4) | 1 (1) | 0.001 | 17 (5) |
| No follow-up | 6 (33) | 10 (23) | 23 (35) | 36 (32) | 28 (25) | 0.51 | 103 (29) |
Bold values indicate significant P. *Other signifies less common treatments such as scleral buckle, photodynamic therapy, transpupillary thermotherapy, and plaque radiotherapy, NA=Not applicable, VEGF=Vascular endothelial growth factor, Number of total treatments: Post-hoc analysis (Bonferroni test) showed a significant difference between groups 3 and 5 (P<0.001). There was no significant difference between any other groups (P>0.05)