Table 2.

Intra-arterial chemotherapy - drugs and dosage

Drugs	Standard dose in mg	Dose range in mg	Indications
Melphalan*	5	3-7.5	- Drug of choice in groups B and C as single agent
Topotecan	1	1-2	- Advanced retinoblastoma with diffuse vitreous seeds (groups D and C)
Carboplatin	20	15-30	- Tandem IAC - to reduce the cumulative toxicity of melphalan, given alternatively
			- Recurrence after IAC
			- Suboptimal response to melphalan and topotecan combination

*Melphalan has to be filtered before infusion