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. Author manuscript; available in PMC: 2019 Jun 6.
Published in final edited form as: JAMA Psychiatry. 2016 Oct 1;73(10):1048–1055. doi: 10.1001/jamapsychiatry.2016.1478

Table 3.

Serotonin1A ROI Analysis Results for Suicidal Ideation During Follow-upa

Log-Transformed PBF per ROI 3 mo
12 mo
24 mo
Estimate P Value Adjustedb Estimate P Value Adjustedb Estimate P Value Adjustedb
RN 0.02 .001 NA 0.01 <.001 NA −0.008 .21 NA

Amygdala 0.02 <.001 0.002 0.004 .26 0.26 −0.01 .03 0.29

Hippocampus 0.02 <.001 0.002 0.009 .03 0.03 −0.007 .18 0.29

Parahippocampal gyrus 0.01 .01 0.02 0.01 .004 0.02 −0.009 .10 0.29

Temporal lobe 0.01 .005 0.01 0.007 .02 0.03 −0.008 .11 0.29

Anterior cingulate gyrus 0.01 .02 0.02 0.009 .004 0.02 −0.008 .12 0.29

Dorsal PFC 0.01 .02 0.02 0.009 .01 0.02 −0.006 .24 0.29

Medial PFC 0.01 .01 0.02 0.008 .01 0.02 −0.005 .29 0.29

Orbital PFC 0.01 .02 0.02 0.007 .03 0.03 −0.006 .24 0.29

Insula 0.01 .006 0.01 0.009 .006 0.02 −0.005 .29 0.29

Occipital lobe 0.01 .01 0.02 0.008 .01 0.02 −0.006 .22 0.29

Parietal lobe 0.01 .02 0.02 0.008 .01 0.02 −0.007 .16 0.29

Abbreviations: BPF, binding potential; NA, not applicable in the primary analysis; PFC, prefrontal cortex; RN, raphe nuclei; ROI, region of interest.

a

Patients underwent imaging with carbon 11-labeled 3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-benzonitrile ([11C]DASB).

b

Significance levels for exploratory analyses are adjusted using the Benjamini-Hochberg method.