Table 3.
Log-Transformed PBF per ROI | 3 mo |
12 mo |
24 mo |
||||||
---|---|---|---|---|---|---|---|---|---|
Estimate | P Value | Adjustedb | Estimate | P Value | Adjustedb | Estimate | P Value | Adjustedb | |
RN | 0.02 | .001 | NA | 0.01 | <.001 | NA | −0.008 | .21 | NA |
Amygdala | 0.02 | <.001 | 0.002 | 0.004 | .26 | 0.26 | −0.01 | .03 | 0.29 |
Hippocampus | 0.02 | <.001 | 0.002 | 0.009 | .03 | 0.03 | −0.007 | .18 | 0.29 |
Parahippocampal gyrus | 0.01 | .01 | 0.02 | 0.01 | .004 | 0.02 | −0.009 | .10 | 0.29 |
Temporal lobe | 0.01 | .005 | 0.01 | 0.007 | .02 | 0.03 | −0.008 | .11 | 0.29 |
Anterior cingulate gyrus | 0.01 | .02 | 0.02 | 0.009 | .004 | 0.02 | −0.008 | .12 | 0.29 |
Dorsal PFC | 0.01 | .02 | 0.02 | 0.009 | .01 | 0.02 | −0.006 | .24 | 0.29 |
Medial PFC | 0.01 | .01 | 0.02 | 0.008 | .01 | 0.02 | −0.005 | .29 | 0.29 |
Orbital PFC | 0.01 | .02 | 0.02 | 0.007 | .03 | 0.03 | −0.006 | .24 | 0.29 |
Insula | 0.01 | .006 | 0.01 | 0.009 | .006 | 0.02 | −0.005 | .29 | 0.29 |
Occipital lobe | 0.01 | .01 | 0.02 | 0.008 | .01 | 0.02 | −0.006 | .22 | 0.29 |
Parietal lobe | 0.01 | .02 | 0.02 | 0.008 | .01 | 0.02 | −0.007 | .16 | 0.29 |
Abbreviations: BPF, binding potential; NA, not applicable in the primary analysis; PFC, prefrontal cortex; RN, raphe nuclei; ROI, region of interest.
Patients underwent imaging with carbon 11-labeled 3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-benzonitrile ([11C]DASB).
Significance levels for exploratory analyses are adjusted using the Benjamini-Hochberg method.