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. Author manuscript; available in PMC: 2020 May 15.
Published in final edited form as: Biol Psychiatry. 2019 Jan 21;85(10):838–849. doi: 10.1016/j.biopsych.2018.12.023

Figure 5. Comparison of EWAS vs. SLCMA estimates for the top CpG site identified in SLCMA, cg19157140.

Figure 5

The effect estimates and the confidence intervals obtained from the EWAS approach comparing ever exposed to never exposed to financial stress for cg19157140 are presented on the left. The stage 2 effect estimates and confidence intervals obtained from the SLCMA comparing being exposed to neighborhood disadvantage at age 1.75 to being unexposed at age 1.75 for the same CpG site are displayed on the right. The top CpG site in the SLCMA, which suggested a sensitive period at age 1.75 associated with the effects of neighborhood disadvantage, was non-significant after correction for multiple testing (p=0.0002) in the EWAS of neighborhood disadvantage.