Figure 3A.

Spearman correlations of TMAO and precursor molecules with measures of health risks and microbial variables at baseline (n=86). Metabolic score was calculated as the number of factors that were abnormal: 1) high waist circumference (>34.6 inches for women, >40.1 inches for men), 2) low HDL (<40 mg/dl for men or <50 mg/dl for women or taking cholesterol medications), 3) high triglycerides (>150 mg/dl), 4) high glucose (>100 mg/dl), 5) high blood pressure (>130 mm systolic or >85 mm diastolic, or taking blood pressure medications), and 6) insulin resistance by the Homeostatic Model Assessment of Insulin Resistance (HOMA2IR>1.8). The number of samples for which microbiota analyses were available at baseline was 86. The supplementary data shows correlations with the relative abundance of other microbiome variables, but the correlation with Akkermansia mucinophilia was the strongest.