Spearman correlations of TMAO and precursor molecules with measures of
health risks and microbial variables at baseline (n=86). Metabolic score was
calculated as the number of factors that were abnormal: 1) high waist
circumference (>34.6 inches for women, >40.1 inches for men), 2)
low HDL (<40 mg/dl for men or <50 mg/dl for women or taking
cholesterol medications), 3) high triglycerides (>150 mg/dl), 4) high
glucose (>100 mg/dl), 5) high blood pressure (>130 mm systolic or
>85 mm diastolic, or taking blood pressure medications), and 6) insulin
resistance by the Homeostatic Model Assessment of Insulin Resistance
(HOMA2IR>1.8). The number of samples for which microbiota analyses were
available at baseline was 86. The supplementary data shows correlations with the
relative abundance of other microbiome variables, but the correlation with
Akkermansia mucinophilia was the strongest.