Spearman correlations of TMAO and precursor molecules with measures of
health risks and microbial variables after 6 month intervention (n=90).
Metabolic score was calculated as the number of factors that were abnormal: 1)
high waist circumference (>34.6 inches for women, >40.1 inches for
men), 2) low HDL (<40 mg/dl for men or <50 mg/dl for women or
taking cholesterol medications), 3) high triglycerides (>150 mg/dl), 4)
high glucose (>100 mg/dl), 5) high blood pressure (>130 mm
systolic or >85 mm diastolic, or taking blood pressure medications), and
6) insulin resistance by the Homeostatic Model Assessment of Insulin Resistance
(HOMA2IR>1.8). The number of samples for which microbiota analyses were
available at baseline was 90. The supplementary data shows correlations with the
relative abundance of other microbiome variables, but the correlation with
Akkermansia mucinophilia was the strongest.