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. 2019 May 30;9:445. doi: 10.3389/fonc.2019.00445

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Copyright © 2019 Malinovskaya, Ershova, Okorokova, Veiko, Konkova, Kozhina, Savinova, Porokhovnik, Kutsev, Veiko and Kostyuk.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TR-rDNA accumulates in circulating cfDNA of patients with treated breast cancer. Scheme of the human ribosomal repeat. (A) Segment of the rDNA analyzed with NQH is shown. (B) CfDNA concentration for the two groups. Horizontal dotted lines represent the medians. Table below contains statistical data. Each point on the graph is an average of three independent experiments. The main contribution to the overall error of the experiment is made by the step of isolating DNA from the leukocytes. The total standard error was 10 ± 4%. (C) Ribosomal DNA copy number in the cell (genomic) DNA (g-rDNA) and in the plasma cell free DNA (cf-rDNA). Each point on the graph is an average of three independent experiments. The rDNA content was calculated using NQH (44). The total standard error was 11 ± 8%. Two groups do not differ in the content of rDNA in gDNA, but significantly differ in the content of rDNA in cfDNA (the data for the U-test are given). (D) The ratio R = cf-rDNA/g-rDNA; cf-rDNA and g-rDNA are the content of rDNA in cfDNA and gDNA of the same person. Table below contains statistical data. Two groups significantly differ in the ratio R (U-test).