. Author manuscript; available in PMC: 2019 Jun 6.

Published in final edited form as: J Pharm Sci. 2018 Aug 16;107(12):3153–3162. doi: 10.1016/j.xphs.2018.07.032

Table 3.

Plasma Free Drug Noncompartmental Pharmacokinetics Parameters Comparison of Current ATV, RTV, and TFV and Previously Reported Free LPV

Free Drugs
	ATV	RTV^a	TFV^a	LPV
AUC (h·μM)	0.6^b	3.3 (2.6-3.9)^d	85 (72-93)^d	4.8 (4.2-4.6)^c
CL/F (L/[h·kg])	42^b	4.0 (2.3-5.7)^d	0.46 (0.31-0.93)^d	4.6 (4.1-5.3)^c
Terminal t_1/2 (h)	4.3^b	4.2 (3.3-5.9)^d	9.6 (1.4-11.3)^d	8.7 (5.3-10.4)^c
MBRT (h)	5.6^b	10.5 (7.6-13.2)^d	2.5 (1.6-3.5)^d	11.0 (10.6-11.4)^c

Geometric Mean (95% CI).

Free drugs scaled to equivalent DcNP dosages. DcNP containing ATV drugs scaled to equivalent DcNP containing LPV (TLC-ART 101⁴) drug dosages.

DcNP containing LPV (TLC-ART 101) drugs and free LPV values were taken from previous TLC-ART 101 study.⁴

AUC, area under the plasma drug concentration-time curve extrapolated to infinity; t_1/2, apparent terminal plasma drug half-life; CL/F, apparent total clearance; MBRT, mean body residence time extrapolated to infinity; – not detected; NA, not available.

RTV and TFV merged with previous free drugs results.⁴

n = 2.

n = 3.

n = 5.