Table 5.
Target Mononuclear Cell Values of Free Drugs for Current ATV, RTV and TFV and Previously Reported Free LPV
| Free Drugs | ||||
|---|---|---|---|---|
| ATV | RTVa | TFVa | LPV | |
| AUCPBMC (h·μM) | 13b | 59 (29-86)d | 260 (197-301)d | 22 (10-33)c |
| LNMC | ||||
| 24 h (μM) | 0.33b | 0.14 (0.01-0.45)d | 1.81 (0.29-9.3)d | – |
| 192 h (μM) | 0.03b | – | 0.11d | – |
| LNMC/plasma | ||||
| 24 h | 57b | 1.6d | 13d | – |
| LNMC/PBMC | ||||
| 24 h | 11b | 0.76d | 1.8d | – |
Geometric Mean (95% CI).
Free drugs scaled to equivalent DcNP dosages. DcNP containing ATV drugs scaled to equivalent DcNP containing LPV (TLC-ART 1014) drug dosages.
DcNP containing LPV (TLC-ART 101) drugs and free LPV values were taken from previous TLC-ART 101 study.4
AUCPBMC area under the PBMC drug concentration-time curve extrapolated to infinity.
AUCPBMC, area under the PBMC drug concentration-time curve extrapolated to infinity; –, not detected; NA, not available.
a
RTV and TFV merged with previous free drugs results.4
b
n = 2.
c
n = 3.
d
n = 5.