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. Author manuscript; available in PMC: 2020 May 2.
Published in final edited form as: Cell. 2019 May 2;177(4):1022–1034.e6. doi: 10.1016/j.cell.2019.04.014
Yi; Y¯; Var(Yi) Phenotype of individual i; mean phenotype; phenotypic variance
M ; N Number of core genes; total number of genes
γj Mean effect of a unit change in expression of gene j on Yi
xi,j; xj¯ Expression of gene j in individual i; mean expression of gene j
ϵYi Random variation in Yi not mediated through core gene expression
Var(ϵYi) Variance of random phenotypic effects (ϵYi)
Var(ϵxi,j); Cov(xi,j, xi,k) Phenotypic variance of gene j; Phenotypic covariance of genes j and k
ϵxij Random (nongenetic) variation in expression of gene j in individual i
IL Index over causal sites (loci)
Vj; Vj,cis; Vj,trans Genetic variance for gene j; cis and trans genetic variances of j
Cj,k Genetic covariance of genes j and k
Δl Effect size of variant l on expression of gene j