Yi; ; Var(Yi) |
Phenotype of individual i; mean phenotype; phenotypic variance |
M ; N
|
Number of core genes; total number of genes |
γj |
Mean effect of a unit change in expression of gene j on Yi
|
xi,j;
|
Expression of gene j in individual i; mean expression of gene j
|
ϵYi
|
Random variation in Yi not mediated through core gene expression |
Var(ϵYi) |
Variance of random phenotypic effects (ϵYi) |
Var(ϵxi,j); Cov(xi,j, xi,k) |
Phenotypic variance of gene j; Phenotypic covariance of genes j and k
|
ϵxij
|
Random (nongenetic) variation in expression of gene j in individual i
|
I…L
|
Index over causal sites (loci) |
Vj; Vj,cis; Vj,trans
|
Genetic variance for gene j; cis and trans genetic variances of j
|
Cj,k |
Genetic covariance of genes j and k
|
Δl
|
Effect size of variant l on expression of gene j
|