Table 3.
Summary of All Codeml Results for Shared Pathways, PSGs, and/or Positively Selected Sites for High-Elevation Species >2,500 m (Colibri coruscans, Aglaeactis castelnaudii, Coeligena violifer, Metallura phoebe, and Patagona gigas peruviana)a
| Species | Shared Pathway/Gene Function under Selection | Shared PSG | Unique PSG | Shared Positively Selected Site |
|---|---|---|---|---|
| C. violifer | Related to autophagy | ATG9A | — | |
| Col. coruscans | — | |||
| C. violifer | Respiratory electron transport, ATP synthesis, metabolism | NDUFB10 | — | |
| P. gigas peruviana | ND1 | — | ||
| High-elevation species >2,500 m | Regulation of the cell cycle | CCNI | Asp80 | |
| Formation of fibrin clot (clotting cascade) | C1QBP | Ala60 | ||
| Mitochondrial translation; organelle biogenesis and maintenance | MRPS26 | Val275 | ||
| Respiratory electron transport, oxidative phosphorylation | UQCRQ | Gly3, Ser4 | ||
| Metabolism of proteins; mitochondrial protein import | TIMM17A | Lys1, Asp2, Lys3 | ||
| Negative regulation of angiotensin II (causes vasoconstriction and increase in blood pressure) signaling | AGTRAP | — |
a
From left to right, the table shows the group of species that share pathways, PSGs, and positively selected sites (yes–yes–yes), share pathways and PSGs but not sites (yes–yes–no), and that have different PSGs involved in similar pathways/functions (yes–no–no). For shared sites, we show the reference amino acid (first sequence in alignment) and site position, otherwise a dash is shown if no positively selected sites were identified or shared.