Figure 3.

Sequence motifs associated with 6mA positions. We extracted 50 bp of sequence surrounding each 6mA position and used Homer (Heinz et al. 2010) to search for enriched motifs within these sequences. Four of the motifs identified by Homer are low-complexity sequences, including two GA-rich sequences (motifs 1, 2, 3, and 5). Three motifs are similar to those recognized by developmental transcription factors including the CBF family, Bicoid, and Caudal (motifs 4, 6, and 10), and three others are similar to motifs recognized by genes involved in RNA processing: U1 snRNP, Fmr1, Top2 (motifs 8, 9, and 13).