Table 2. Cyclin C-Dependent Genes. GO-Functional Annotation Clusters for cyclin C-dependent genes. The following clusters (1-5) resulting from DAVID-GO Functional Annotation Clustering, represent the overlapping genes downregulated in both WT Stress and Ccnc−/− MEFs (876 genes).
| Cyclin C-Dependent Genes | |||||
|---|---|---|---|---|---|
| Cluster | ES | Category | Associated Term | p-value | Genes Involved (#) |
| 1 | 6.16 | UP KEYWORDS | Oxidoreductase | 1.08E-7 | 54 |
| GOTERM BP DIRECT | Oxidation-reduction process | 7.10E-7 | 58 | ||
| GOTERM MF DIRECT | Oxidoreductase activity | 1.69E-6 | 53 | ||
| 2 | 5.94 | UP KEYWORDS | Lipid metabolism | 2.65E-7 | 40 |
| GOTERM BP DIRECT | Lipid metabolic process | 4.72E-7 | 45 | ||
| UP KEYWORDS | Lipid biosynthesis | 1.18E-5 | 20 | ||
| 3 | 5.17 | GOTERM MF DIRECT | Cadherin binding involved in cell-cell adhesion | 1.44E-6 | 32 |
| GOTERM CC DIRECT | Cell-cell adherens junction | 3.70E-6 | 33 | ||
| GOTERM BP DIRECT | Cell-cell adhesion | 5.89E-5 | 22 | ||
| 4 | 3.91 | KEGG PATHWAY | Rap 1 signaling pathway | 7.73E-7 | 29 |
| KEGG PATHWAY | P13K-Akt 1 signaling pathway | 2.40E-4 | 33 | ||
| KEGG PATHWAY | Ras signaling pathway | 1.18E-2 | 20 | ||
| 5 | 3.67 | UP KEYWORDS | Differentiation | 9.10E-6 | 49 |
| UP KEYWORDS | Developmental protein | 1.90E-4 | 61 | ||
| GOTERM BP DIRECT | Multicellular organism development | 5.72E-3 | 62 | ||
ES = Enrichment score produced by Functional Annotation Clustering in DAVID.
Category Terms Defined: UP Keywords = Uniprot Keywords; GOTERM BP DIRECT = GO Term for Direct Involvement in Biological Process; GOTERM MF DIRECT = GO Term for Direct Involvement in Molecular Function; GOTERM CC DIRECT = GO Term for Direct Localization to Cellular Compartment; KEGG PATHWAY = KEGG Pathway.