Table 3. Cyclin C-Repressed Genes. GO-Functional Annotation Clusters for cyclin C-repressed genes. The following clusters (1-5) resulting from DAVID-GO Functional Annotation Clustering, represent the overlapping genes upregulated in both WT Stress and Ccnc−/− MEFs (499 genes).
| Cyclin C-Repressed Genes | |||||
|---|---|---|---|---|---|
| Cluster | ES | Category | Associated Term | p-value | Genes Involved (#) |
| 1 | 3.69 | UP KEYWORDS | Protein transport | 4.46E-6 | 32 |
| GOTERM BP DIRECT | Protein transport | 6.48E-6 | 34 | ||
| UP KEYWORDS | Transport | 6.02E-3 | 59 | ||
| GOTERM BP DIRECT | Transport | 1.03E-2 | 60 | ||
| 2 | 3.39 | UP KEYWORDS | DNA damage | 5.54E-5 | 21 |
| GOTERM BP DIRECT | Cellular response to DNA damage stimulus | 8.19E-5 | 25 | ||
| GOTERM BP DIRECT | DNA repair | 1.80E-3 | 18 | ||
| 3 | 3.14 | GOTERM CC DIRECT | Lysosomal membrane | 3.16E-5 | 18 |
| UP KEYWORDS | Lysosome | 1.22E-3 | 15 | ||
| GOTERM CC DIRECT | Lysosome | 1.01E-2 | 16 | ||
| 4 | 3.13 | GOTERM BP DIRECT | Protein ubiquitination | 7.44E-6 | 25 |
| UP KEYWORDS | Ubl conjugation pathway | 6.24E-5 | 31 | ||
| GOTERM MF DIRECT | Ubiquitin-protein transferase activity | 2.68E-2 | 15 | ||
| 5 | 2.10 | UP KEYWORDS | Unfolded protein response | 1.09E-5 | 8 |
| GOTERM BP DIRECT | Response to unfolded protein | 2.00E-4 | 8 | ||
ES = Enrichment score produced by Functional Annotation Clustering in DAVID.
Category Terms Defined: UP Keywords = Uniprot Keywords; GOTERM MF DIRECT = GO Term for Direct Involvement in Molecular Function; GOTERM BP DIRECT = GO Term for Direct Involvement in Biological Process; GOTERM CC DIRECT = GO Term for Direct Localization to Cellular Compartment.