TABLE 3.

Molecular function enrichment of gene expression changes in confluent HFFs upon tachyzoite infection

GO term	Function	Padj
Upregulated
GO:0003677	DNA binding	2.26E−13
GO:0046982	Protein heterodimerization activity	2.74E−11
GO:0042393	Histone binding	5.18E−11
GO:0097159	Organic cyclic compound binding	5.58E−08
GO:1901363	Heterocyclic compound binding	5.97E−08
GO:0003676	Nucleic acid binding	1.08E−05
GO:0036094	Small molecule binding	5.55E−05
GO:0000166	Nucleotide binding	1.07E−04
GO:1901265	Nucleoside phosphate binding	1.12E−04
GO:0035575	Histone demethylase activity (H4-K20 specific)	1.44E−04
GO:0003688	DNA replication origin binding	4.10E−04
GO:0003678	DNA helicase activity	5.19E−04
GO:0005515	Protein binding	9.61E−04
GO:0097367	Carbohydrate derivative binding	1.43E−03
GO:0003697	Single-stranded DNA binding	3.77E−03
GO:0043168	Anion binding	4.58E−03
GO:0032451	Demethylase activity	4.89E−03
GO:0005488	Binding	5.93E−03
GO:0005200	Structural constituent of cytoskeleton	9.56E−03
GO:0032405	MutLalpha complex binding	1.03E−02
GO:0050501	Hyaluronan synthase activity	4.11E−02
Downregulated
GO:0005539	Glycosaminoglycan binding	3.81E−03
GO:0005518	Collagen binding	3.10E−02
GO:0036122	BMP bindinga	3.10E−02
GO:0048018	Receptor agonist activity	3.32E−02

^aBMP, bone morphogenetic protein.