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. 2019 May 6;374(1775):20180255. doi: 10.1098/rstb.2018.0255

Figure 1.

Figure 1.

Disease tetrahedron; modified after Zadoks & Schein [22]. Nodes correspond to the main determinants of a disease outbreak: host, pathogen, environment and man. The thick double arrow represents the host–pathogen axis. Thin solid arrows indicate the influence of environment on the host–pathogen combination. Broken arrows represent the human factor affecting all components.