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Illustration showing the mechanism of central and peripheral leptin signaling. ADRB2 = B2 adrenergic receptor, BMSCs = bone marrow stromal cells, LEPR = leptin receptor. (Reproduced with permission from Macmillan Publishers Ltd, Kawai M, Devlin MJ, Rosen CJ: Fat targets for skeletal health. Nat Rev Rheumatol 2009;5:365-372.)
