Table 1. Comparison of adverse effects of prucalopride with other drugs used in chronic constipation.

Drugs	Adverse Effects	Reference number
Prucalopride	Abdominal pain, diarrhea, nausea, and headache	[14]
Velusetrag	Diarrhea, headache, nausea, vomiting, flatulence, and abdominal pain	[30]
Lubiprostone	Vomiting, nausea, and abdominal cramping	[31]
Linaclotide	Diarrhea	[32]
Plecanatide	Diarrhea, sinusitis, upper respiratory tract infection, abdominal distension, flatulence, abdominal tenderness, and increased levels on liver biochemical tests	[33]