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. 2019 Jun 6;14(6):e0217881. doi: 10.1371/journal.pone.0217881

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© 2019 Jablonska et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 3 — a) Axial fat-saturated contrast-enhanced T1-weighted image (CE T1-WI) MRI 4 months after HFRT/TMZ, showing mostly linear enhancement surrounding the surgical cavity in left temporal lobe. b) Axial CE T1-WI of the same patient 2 months later (6 months after HFRT/TMZ), shows increased enhancement with a "soap-bubble" pattern, suggestive of radiation necrosis/pseudoprogression. c) Axial perfusion-weighted cerebral brain volume (CBV) map fused over CE T1-WI shows decreased perfusion values in the enhancing area, further supporting radiation necrosis.