Table 3.
Linear regression models with VO2max as the outcome, stratified by altitude
| Unadjusted analysis | Multivariable-adjusted analysis | |||||||
|---|---|---|---|---|---|---|---|---|
| Coefficient | 95% CI | P- value | Coefficient | 95% CI | P-value | |||
| Schistosoma mansoni egg patent infection* | ||||||||
| Low altitude | −1.299 | −2.389 | −0.208 | 0.020 | −3.962 | −6.556 | −1.368 | 0.004 |
| High altitude | −0.971 | −2.712 | 0.770 | 0.271 | 0.452 | −5.102 | 6.007 | 0.866 |
| Fecal occult blood | ||||||||
| Low altitude | −0.610 | −1.349 | 0.128 | 0.104 | −0.226 | −1.362 | 0.911 | 0.690 |
| High altitude | 0.592 | −0.333 | 1.518 | 0.205 | 0.694 | −1.094 | 2.482 | 0.424 |
| Malaria† | ||||||||
| Low altitude | −0.938 | −2.320 | 0.444 | 0.182 | −2.121 | −4.390 | 0.148 | 0.066 |
| High altitude | 2.832 | 0.494 | 5.170 | 0.019 | 5.524 | 0.084 | 10.964 | 0.047 |
| Stunting‡ | ||||||||
| Low altitude | −0.448 | −1.749 | 0.853 | 0.498 | −0.126 | −2.715 | 2.463 | 0.922 |
| High altitude | −0.719 | −2.875 | 1.438 | 0.510 | −0.842 | −6.230 | 4.547 | 0.746 |
| Anemia§ | ||||||||
| Low altitude | −0.924 | −2.145 | 0.297 | 0.137 | 0.891 | −1.418 | 3.201 | 0.440 |
| High altitude | −0.326 | −2.076 | 1.424 | 0.711 | −1.834 | −5.384 | 1.717 | 0.291 |
AIC = Akaike’s information criterion. Statistically significant differences (P ≤ 0.05) indicated in bold.
* As per dual Kato–Katz examination.
† As per malaria rapid diagnostic testing.
‡ According to validated stunting charts based on height-for-age Z-score ≤ 2 SD below mean.35
§ As per standardized hemoglobin cutoffs for age: < 11.5 g dL−1 (5–11 years) and < 12.0 g dL−1 (12–14 years). Hemoglobin adjusted for altitude.39 For multivariable-adjusted analysis, low altitude: n = 45. P-value = 0.022. R2 = 0.277. Adjusted R2 = 0.184. AIC = 246.900. High altitude: n = 23. P-value = 0.202. R2 = 0.326. Adjusted R2 = 0.128. AIC = 125.111.