Table 5.

Summary of post-CHMI malaria-related symptoms in blood smear–positive participants

Days from CHMI to	Statistic	MC-001 (N = 6)	MC-003 infectivity and drug controls (N = 11)	MC-003 vaccinated (N = 14)	PfSPZ-Cvac PYR (N = 6)	All studies (N = 37)
First symptom (any grade)	N	6	11	14	4	35
	Mean (days)	9.7	8.2	9.8	12.8	9.7
	95% CI (days)	6.4–12.2	7.2–9.1	8.5–11.1	10.4–14.2	8.9–10.4
First grade 2 symptom	N	5	10	9	4	28
	Mean (days)	12.2	8.8	10.0	13.8	10.7
	95% CI (days)	10.6–13.3	7.9–9.6	8.2–11.8	12.2–14.7	9.7–11.6

CHMI = controlled human malaria infection; PYR = pyrimethamine.