Table I. Selected mitochondrial proteins after the proteomic shotgun analysis.

Fasta headers	UniProt ID	Rapa/control	T-test rapa	Zn/control	T-test Zn
Complex II subunits
Succ. Dehydrogenase sub.Ac	P31040	1.29	0.048	1.19	0.057
Succ. Dehydrogenase sub.B	P21912	1.20	0.0047	1.132	0.19
Complex IIIa subunits
Complex III subunit 1	P31930	1.10	0.16	1.22	0.015
Complex III subunit 2	P22695	1.08	0.17	1.23	0.012
Complex III subunit 6	P07919	1.05	0.98	1.08	0.88
Complex III subunit 7	P14927	1.02	0.88	1.18	0.54
Complex III subunit 8	O14949	0.91	0.65	1.04	0.93
Complex III subunit 9	Q9UDW1	0.87	0.37	0.78	0.21
Complex V subunits
ATP synthase subunit alpha	P25705	1.01	0.88	1.12	0.34
ATP synthase subunit beta	P06576	1.93	0.050	1.61	0.13
ATP synthase subunit gamma	P36542	0.94	0.84	1.03	0.82
ATP synthase subunit delta	P30049	2.25	0.0050	1.63	0.022
ATP synthase subunit d	O75947	1.10	0.49	1.18	0.36
ATP synthase subunit e	P56385	0.828	0.29	0.76	0.29
ATP synthase subunit f	P56134	0.90	0.51	1.14	0.50
ATP synthase subunit g	O75964	0.87	0.36	0.99	0.90
ATP synthase subunit O	P48047	0.96	0.85	1.14	0.59
ATP synthase subunit s	Q99766	1.01	0.99	1.03	0.98
ATP synthase subunit 8	P03928	1.14	0.47	1.06	0.75
ATP synthase coupling fact. 6	P18859	1.78	0.14	1.82	0.022
ATP synth. assembly fact. 2	Q8N5M1	0.53	0.026	0.44	0.14
Enzymesb
Valacyclovir hydrolase	Q86WA6	0.47	0.0033	0.60	0.028
d-2 hydroxyglutarate DH	Q8N465	0.51	0.029	1.01	0.89
l-2 hydroxyglutarate DH	Q9H9P8	0.82	0.040	0.95	0.62
Pyruvate DH phosphatase 1	Q9P0J1	0.73	0.029	0.70	0.079
Pyruvate DH phosphatase reg	Q8NCN5	0.72	0.031	0.64	0.061
Pyruvate DH kinase 1	Q15118	1.43	0.048	1.28	0.35
Pyruvate DH kinase 3	Q15120	1.07	0.38	1.38	0.0061
Isocitrate DH (NAD) sub. beta	O43837	0.76	0.059	0.82	0.049
Isocitrate DH (NAD) sub. alpha	P50213	0.97	0.91	0.85	0.49
Isocitrate DH sub. gamma	P51553	0.72	0.034	0.86	0.21
Glutaminase	O94925	0.48	0.0038	0.81	0.096
Citrate synthase	O75390	0.72	0.09	0.70	0.017
Proteases
Lon protease homolog	P36776	0.71	0.18	0.56	0.051
Clp Protease catal. subunit	Q16740	0.51	0.04	0.61	0.031
Mito. Intermediate peptidasec	Q99797	0.553	0.0017	0.65	0.011
Mito. processing protease betac	O75439	0.64	0.079	0.69	0.045
Mito. processing protease alpha	Q10713	0.80	0.563	0.85	0.691

^a complex III: ubiquinol-cytochrome c reductase complex.

^b DH = dehydrogenase.

^c normalized peptide intensities for these proteins are provided in Supplementary Table V.

Rapa, Rapamycin; Zn, Zinc.