Table 1.

Association of nuclear GAPDH and HIF-1α expression with clinicopathologic characteristics in 137 HCC patients

Variables	n	HIF-1α Expression			Nuclear GAPDH expression			p*
low	High	p*	n	low	High
Age				0.930				0.366
≤Y50	70	35	35		70	46	24
˃Y50	67	34	33		67	39	28
Gender				0.372				0.068
Male	115	56	59		115	71	44
Female	22	13	9		22	14	8
Cirrhosis				0.283				0.105
Yes	97	46	51		97	56	41
No	40	23	17		40	29	11
Hepatitis				0.604				0.768
Yes	117	60	57		117	72	45
No	20	9	11		20	13	7
HBsAg				0.849				0.731
Positive	114	57	57		114	70	44
Negative	23	12	11		23	15	8
HBeAg				0.869				0.705
Positive	29	15	14		29	19	10
Negative	108	54	54		108	66	42
TNM				0.002				0.026
I	65	42	23		65	34	31
II-IV	72	27	45		72	51	21
Tumor size				<0.001				0.256
≤5cm	58	18	40		83	46	33
˃5cm	79	51	28		54	38	18
Vascular invasion				<0.001				0.007
Yes	57	17	40		54	41	13
No	80	52	28		83	44	39
ALT, U/L				0.809				0.212
≤80(1.34)	90	46	44		88	58	30
˃80(1.34)	47	23	24		49	27	22
Total bilirubin, µmol/L				0.081				0.840
≤1.0 (17.1)	89	50	39		91	57	34
˃1.0 (17.1)	48	19	29		46	28	18
Albumin, g/L				0.797				0.581
≥35	27	13	14		110	67	43
<35	110	56	54		27	18	9
AFP, µg/L				0.071				0.304
≤400	63	37	26		63	42	21
˃400	74	32	42		74	43	31

Note: *p<0.05 is considered significantly different.

Abbreviations: GAPDH, glyceraldehyde-3-phosphate dehydrogenase; HIF-1α, hypoxia-inducible factor 1α; HCC, hepatocellular carcinoma; HBsAg, hepatitis B surface antigen; HbeAg, hepatitis Be antigen; ALT, alamine aminotransferase; AFP, alpha fetoprotein.