Table 3.
Univariate and multivariate analyses of factors associated with OS and TTR in 137 cases of HCC patients
| Variable | OS | TTR | ||||||
|---|---|---|---|---|---|---|---|---|
| Multivariate analysis | Multivariate analysis | |||||||
| Univariate p* | HR | 95%CI | p* | Univariate p* | HR | 95%CI | p* | |
| Age, year: ≤50 vs >50 | 0.690 | 0.291 | ||||||
| Sex: Female vs male | 0.514 | 0.251 | ||||||
| Hepatitis: No vs yes | 0.287 | 0.794 | ||||||
| HBsAg: Positive vs negative | 0.440 | 0.832 | ||||||
| HBeAg: Positive vs negative | 0.895 | 0.934 | ||||||
| Liver cirrhosis: No vs yes | 0.118 | 0.151 | ||||||
| ALT, U/L: ≤80 vs >80 | 0.099 | 0.091 | ||||||
| Total bilirubin (Tbil) | 0.551 | 0.470 | ||||||
| Albumin (Alb) | 0.227 | 0.540 | ||||||
| Tumor size: ≤5 vs >5 | <0.001 | 1.699 | 0.852–3.387 | 0.132 | 0.046 | 0.778 | 0.453–1.337 | 0.364 |
| Vascular invasion (VI) | 0.017 | 1.013 | 0.509–2.014 | 0.971 | <0.001 | 1.306 | 0.715–2.384 | 0.385 |
| TNM: I vs II-III | 0.014 | 1.084 | 0.562–2.094 | 0.809 | <0.001 | 1.825 | 1.033–3.224 | 0.038 |
| AFP: ≤400 vs >400 | 0.010 | 2.339 | 1.217–4.498 | 0.011 | 0.039 | 1.643 | 0.999–2.702 | 0.050 |
| Nuclear GAPDH | 0.012 | 0.001 | ||||||
| HIF-1α | <0.001 | <0.001 | ||||||
| Combined HIF-1α and Nuclear GAPDH | <0.001 | 2.491 | 1.211–5.121 | 0.002 | <0.001 | 1.976 | 1.048–3.727 | 0.005 |
Note: *p<0.05 is considered significantly different.
Abbreviations: HBsAg, hepatitis B surface antigen; HbeAg, hepatitis Be antigen; ALT, alamine aminotransferase; AFP, alpha fetoprotein; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; HIF-1α, hypoxia-inducible factor 1α; HR,hazard ratio; CI, confidence interval; OS, overall survival; TTR, time to recurrence; HCC, hepatocellular carcinoma.