Figure 3.

We propose an engineered approach using nanocarriers in PDAC, which can overcome stromal vascular gate or suppress the stromal abundance by the delivery of drugs that suppress pericyte coverage or decreases the stromal volume and abundance of deaminase activity. Moreover, a combination of these features could be used in synergistic designed nanocarriers. It is also a possible to include tumor targeting or the use of peptides that induce transcytosis across the stromal barrier.