Table 1.
Subtype-specific RAV persistence.
| Median persistence (months) | ||||
|---|---|---|---|---|
| Residue | RAV | Subtype 1a | Subtype 1b | Reference |
| V36 | A | 2.8 | 3.6 | Sullivan et al. (3) |
| M | 9.3 | 6.3 | ||
| T54 | A | 2.3 | 2.8 | Sullivan et al. (3) |
| S | 11.5 | 1.8 | ||
| V55 | A | ND# | 57 | Susser et al. (57) |
| Q80 | K | 36 | 24 | Lenz et al. (24) |
| R155 | K | 9.8 | -* | Sullivan et al. (3) |
| A156 | S | 6.7 | 8.2 | Sullivan et al. (3) |
| T | 1.8 | 2.7 | ||
| D168 | A | 5 | ND# | Manns et al. (58) Krishnan et al. (59) |
| V | ND# | >9 | Zeuzem et al. (LEAGUE-1) (60) Lenz et al. (24) Krishnan et al. (59) |
|
| N | >6 | ND# | Buti et al. (C-SALVAGE) (61) | |
| I170 | V | ND# | ND# | |
Time to loss of NS3–4A protease RAVs reported in the literature as detected by population and/or clonal sequencing.
#
ND, no data available;
*
No RAVs observed.