Table 2.

Consensus residue-interaction network topology measures.

	Subtype
Topology measure	1a	1b
Radius	6	6
Diameter	12	11
Ave. path length	4.777	4.785
Ave. clustering coefficient	0.422	0.408
Ave. number of neighbors	6.157	5.78
Density	0.035	0.034
Connected nodes	178	173
Isolated nodes	3	7
Combi edges (unique*)	548 (77)	500 (29)
Common** combi edges	85.9%	94.2%
Contact edges (unique*)	726 (184)	676 (129)
H-bond edges (unique*)	89 (30)	74 (15)

^*Edges unique to either the subtype 1a or 1b residue-interaction network;

^**Edges common to both subtype 1a and 1b residue-interaction networks.