Table 3.

Network topology of protease inhibitor resistance-associated sites.

			Topology measures
Class	Res	Subtype	Degree	Clust	Clos	Betw
L	36	1a	0.022	0.333	0.211	0.001
		1b	0.022	0.167	0.224	0.003
	54	1a	0.050	0.250	0.282	0.125
		1b	0.050	0.250	0.269	0.100
	55	1a	0.050	0.278	0.262	0.052
		1b	0.039	0.429	0.249	0.034
	170	1a	0.044	0.286	0.257	0.037
		1b	0.034	0.400	0.245	0.022
M*	80	1a	0.039	0.476	0.222	0.006
		1b	0.034	0.467	0.214	0.007
B	155	1a	0.050	0.278	0.262	0.043
		1b	0.056	0.222	0.262	0.072
	156	1a	0.028	0.500	0.235	0.007
		1b	0.028	0.500	0.229	0.008
	168	1a	0.022	0.333	0.222	0.004
		1b	0.022	0.167	0.217	0.006

Class: class of compound (L – linear, M – macrocyclic, B – both) (22); Res: residue; Degree: degree centrality; Clust: clustering coefficient; Clos: closeness centrality; Betw: betweenness centrality. All values are rounded for better readability.

^*Exception: Sovaprevir (22)