Fig. 1.

Tau protein isoforms in the human CNS. Six tau isoforms are present in the brain. N1 (green) and N2 (blue) are produced through the alternative splicing of exons 2 and 3 respectively. Exon 10 encodes the second aspect of the microtubule-binding repeat domain, R2 (red). Depending on the presence of the R2 domain, tau proteins are termed either 3R-tau or 4R-tau. (Figure used with permission from BMB Rep. Park SA, Ahn SI, Gallo J-M. Tau mis-splicing in the pathogenesis of neurodegenerative disorders. BMB Rep. 2016;49:405–413)