Fig. 4.

PET images of THK compounds. [¹⁸F]AV-1451 (T807). [¹⁸F]AV-1451 (flortaucipir, T807) exhibited strong and selective binding affinity to PHF-tau on AD brain [13, 30]. With favourable pharmacokinetics and a binding pattern consistent with the Braak staging, [¹⁸F]AV-1451 is considered as the most promising PET candidates for tau imaging [21]. Clinical [¹⁸F]AV-1451 PET scans are demonstrated in Fig. 5. (THK-523 This research was originally published in Alzheimers Res. Ther) [29] (THK-5105 and THK-5351 Images courtesy of Prof. Nobuyuki Okamura, Tohoku University) (THK-5117 Reprinted by permission from Copyright Clearance Center. This research was originally published in Springer Nature, Eur. J. Nucl. Med. Mol. Imaging [28] Copyright (2015)