Table 1.
Changes in acylcarnitines and malonate levels when treated with HNG
| Metabolite | CID | Pathway | Fold change | p value |
|---|---|---|---|---|
| 3-Hydroxybutyrylcarnitine | 53481617 | Fatty acid metabolism | 0.39 | 0.010 |
| Acetylcarnitine | 1 | Fatty acid metabolism | 0.79 | 0.241 |
| Adipoylcarnitine | 71296139 | Fatty acid metabolism | 0.54 | 0.032 |
| Cis-4-decenoyl carnitine | 57357170 | Fatty acid metabolism | 0.68 | 0.120 |
| Decanoylcarnitine | 10245190 | Fatty acid metabolism | 0.77 | 0.206 |
| Hexanoylcarnitine | 6426853 | Fatty acid metabolism | 0.62 | 0.210 |
| Laurylcarnitine | 10427569 | Fatty acid metabolism | 0.77 | 0.285 |
| Linoleoylcarnitine | 6450015 | Fatty acid metabolism | 0.72 | 0.025 |
| Myristoleoylcarnitine | 129691961 | Fatty acid metabolism | 0.71 | 0.088 |
| Myristoylcarnitine | 6426854 | Fatty acid metabolism | 0.73 | 0.156 |
| Octanoylcarnitine | 123701 | Fatty acid metabolism | 0.86 | 0.556 |
| Oleoylcarnitine | 6441392 | Fatty acid metabolism | 0.71 | 0.009 |
| Palmitoleoylcarnitine | 71464547 | Fatty acid metabolism | 0.66 | 0.044 |
| Palmitoylcarnitine | 461 | Fatty acid metabolism | 0.82 | 0.113 |
| Stearoylcarnitine | 6426855 | Fatty acid metabolism | 0.93 | 0.203 |
| Malonate | 867 | Fatty acid synthesis | 0.74 | 0.049 |
Bold indicates significant difference (p ≤ 0.05), metabolite ratio of < 1.00