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. 2019 Jun 6;10:2489. doi: 10.1038/s41467-019-10129-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Change in expression in Dp1Tyb mouse embryonic fibroblasts (MEFs) as a function of chromosomal position. Plots show fold change of gene expression in Dp1Tyb MEFs vs wild-type control cells. Expressed genes are plotted in chromosomal order on the four example chromosomes. Genes that are significantly differentially expressed are indicated with blue dots, other genes are in grey. A Loess smoothing curve is superimposed with regions that are upregulated or downregulated indicated in red or green. Dashed line on Mmu16 indicates a fold change of 1.5. Note the upregulation of genes in the duplicated region on Mmu16 (thick black line)