Table 1.
Human DS fibroblasts3 and mouse Dp1Tyb MEFs and hippocampus show GEDDs
| Sample | Number of significant chromosomes | |
|---|---|---|
| Flips | Energy | |
| Human DS fibroblasts | 20 | 22 |
| Dp1Tyb MEFs | 7 | 16 |
| Dp1Tyb hippocampus | 8 | 17 |
Table shows the numbers of chromosomes that had significantly (>2 SD) reduced numbers of flips or increased energy in comparisons of changes in gene expression in human DS vs euploid fibroblasts or in Dp1Tyb vs WT MEFs or hippocampus
DS, Down syndrome; GEDD, gene expression dysregulation domain; MEF, mouse embryonic fibroblast