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. 2019 Jun 6;10(6):451. doi: 10.1038/s41419-019-1670-6

Fig. 1. Elevated nuclear p53 and progerin are closely related to cell premature senescence in liver fibrosis patients.

Fig. 1

a The H&E in liver biopsy specimens of patients (Scale bar: 100 μm). b The quantified analysis of liver fibrosis with ISHAK and Metavir score. *P < 0.05 versus the normal group. c Masson staining and SA-β-gal staining in liver biopsy specimens (Scale bar: 100 μm). SA-β-gal positive cells, which implied senescent cells, were blue stained. d The semiquantified analysis of Masson staining and SA-β-gal staining. *P < 0.05 versus the normal group. e The immunohistochemical staining (IHC) for p53 and progerin in liver biopsy specimens (Scale bar: 50 μm). f The semiquantitative score of IHC staining for p53 and progerin. *P < 0.05 versus the normal group