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. 2019 Jun 6;10(6):451. doi: 10.1038/s41419-019-1670-6

Fig. 2. IGF-1 gene transfer to CCl4-induced rat models alleviates hepatic steatosis and fibrogenesis.

Fig. 2

a The plasm IGF-1 content of CCl4-induced rat models on Day 6 and Day 28. *P < 0.05 versus the Vehicle group on Day 6; #P < 0.05 versus the CCl4 + LV-CTR group on Day 6; &P < 0.05 versus the Vehicle group on Day 28; $P < 0.05 versus the CCl4 + LV-CTR group on Day 28. b The ALT content of CCl4-induced rat models on Day 6 and Day 28. *P < 0.05 versus the Vehicle group on Day 6; #P < 0.05 versus the CCl4 + LV-CTR group on Day 6; &P < 0.05 versus the Vehicle group on Day 28; $P < 0.05 versus the CCl4 + LV-CTR group on Day 28. c The H&E and Masson staining in liver biopsy specimens of CCl4-induced rat models on Day 6 and Day 28. (Scale bar: 100 μm). d The quantitation with ISHAK and Metavir score in liver biopsy specimens of CCl4-induced rat models on Day 6 and Day 28. *P < 0.05 versus the Vehicle group on Day 6; #P < 0.05 versus the CCl4 + LV-CTR group on Day 6; &P < 0.05 versus the Vehicle group on Day 28; $P < 0.05 versus the CCl4 + LV-CTR group on Day 28. e The area density of Masson staining in rat liver tissue on Day 6 and Day 28. *P < 0.05 versus the Vehicle group on Day 6; #P < 0.05 versus the CCl4 + LV-CTR group on Day 6; &P < 0.05 versus the Vehicle group on Day 28; $P < 0.05 versus the CCl4 + LV-CTR group on Day 28. n = 6 per group