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. 2019 Jun 6;10(6):451. doi: 10.1038/s41419-019-1670-6

Fig. 3. IGF-1 gene transfer to CCl4-induced rat models alleviates hepatocyte premature senescence.

Fig. 3

a The SA-β-gal staining, as well as the IHC staining for p53 and progerin in liver biopsy specimens of CCl4-induced rat models on Day 6 and Day 28. (Scale bar: 50 μm). b The semiquantitative score of SA-β-gal staining of rat liver tissue on Day 6 and Day 28. *P < 0.05 versus the Vehicle group on Day 6; #P < 0.05 versus the CCl4 + LV-CTR group on Day 6; &P < 0.05 versus the Vehicle group on Day 28; $P < 0.05 versus the CCl4 + LV-CTR group on Day 28. c The semiquantitative score of IHC staining for p53 of rat liver tissue on Day 6 and Day 28. *P < 0.05 versus the Vehicle group on Day 6; #P < 0.05 versus the CCl4 + LV-CTR group on Day 6; &P < 0.05 versus the Vehicle group on Day 28; $P < 0.05 versus the CCl4 + LV-CTR group on Day 28. d The semiquantitative score of IHC staining for progerin of rat liver tissue on Day 6 and Day 28. *P < 0.05 versus the Vehicle group on Day 6; #P < 0.05 versus the CCl4 + LV-CTR group on Day 6; &P < 0.05 versus the Vehicle group on Day 28; $P < 0.05 versus the CCl4 + LV-CTR group on Day 28. n = 6 per group