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. 2019 Jun 6;10(6):448. doi: 10.1038/s41419-019-1671-5

Fig. 2. Overexpression of microRNA-708 (miR-708) decreased glioma cell growth both in vitro and in vivo.

Fig. 2

a Cell viability was decreased in the LV-miR-708 group when compared with that in the LV-ctrl group. b Restoration of miR-708 decreased LN382 and GBM-GY cell proliferation, as determined by colony formation assay. c 5-Ethynyl-2′-deoxyuridine (EdU) assay revealed that the number of LV-miR-708 cells stained with EdU was less than that of LV-ctrl cells stained with EdU. d Cell cycle was arrested in the G1 phase when miR-708 was overexpressed in glioma cells. e Western blot assay present the altered G1/S-phase checkpoint protein expression in the LV-miR-708 group. f Glioma cells in the LV-miR-708 group grew slower than cells in the LV-ctrl group. g Xenograft tumors from the LV-miR-708 group were smaller than that from the LV-ctrl group. h Immunohistochemical (IHC) assay revealed that the Ki-67 staining index was decreased in the LV-miR-708 group when compared with that in the LV-ctrl group