Fig. 3.

Acute and repeated measurement of the hypothermic effect of compound MCR9 in mice. a Effect of acute treatment with MCR9 (20 mg/kg, i.p.) on rectal body temperature in mice. Columns are means ± SEM of the difference (Δ, 1 h - basal value) in body temperature (°C) for MCR9-treated mice compared with vehicle-treated Control mice. Data were analyzed using Student’s t-test. **p<0.01. b Effect of repeated (5 days) treatments with MCR9 (20 mg/kg, i.p., closed circles) on rectal body temperature in mice. Circles are means ± SEM of the difference (Δ, 1 h - basal value) in body temperature (°C) for MCR9-treated mice compared with vehicle-treated Controls. Data were analyzed using repeated measures ANOVA followed by Sidak’s multiple comparison test. **p<0.01, ***p<0.001; (n=6−7 animals per group)