Fig. 4.
Behavioral and cognitive improvement in 12-month-old treated SAMP8 mice with both I2-IR ligands. a A significant increase in the distance traveled in the open field test in the I2-IR ligand treated groups compared with the Control group. b A significant increase in the percentage of time in the center zone of the opened field test in the MCR5 treated group compared with the Control group, and no significant difference between the MCR9 and Control groups. c A significant increase in the number of total rears of the opened field test among groups. d The time spent in the opened arms of the EPM did not differ among groups. e A significant increase in the time spent in the closed arms among the Control group compared with the treated groups. f A significant increase in the number of total rears of the EPM in the MCR5 group compared with the Control group. g The results of the NORT in the short-term memory (2 h) revealed a significant increase in both I2-IR ligand treated groups compared with the Control group as well as a significant reduction in the DI of the MCR9 group compared with MCR5 group, and (h) a significant increase in the DI of the long-term memory (24 h) in both I2-IR ligand treated groups compared with the Control group. Data expressed as means ± SEM (n=8-10 animals per group) and analyzed using one-way ANOVA followed by Tukey’s post hoc test for multiple comparisons. *p<0.05, **p<0.01, ***p<0.001 and ****p<0.0001