Fig. 5.

Reduced OS and inflammatory markers in 12-month-old treated SAMP8 mice with both I₂-IR ligands. a There was a significant reduction in the hydrogen peroxide concentration in both I₂-IR ligand treated groups compared with the Control group in homogenates of the hippocampus tissue. b A significant reduction in SOD1 protein levels in the MCR5 group compared with the Control group and no difference between the MCR9 and Control groups. c A significant reduction in Gfap protein levels in the MCR5 and MCR9 groups compared with the Control group. d Gene expression of antioxidant enzymes in the mouse hippocampus. A significant increase in Hmox1 gene expression, but not for Aox1 and Cox2, among both I₂-IR ligand treated groups and the Control group. e A significant reduction in gene expression of Il-1β and Tnf-α in the MCR5 group compared with the Control group, and a tendency for the same genes to reduce in the MCR9 group. However, Il-6 gene expression did not differ among groups. Values in bar graphs are adjusted to 100% for protein level of the Control group. Gene expression levels were determined by real-time PCR. Data are expressed as means ± SEM (n=4-5 animals per group) and analyzed using one-way ANOVA followed by Tukey’s post hoc test for multiple comparisons. *p<0.05