Fig. 6.
Changes in synaptic markers and apoptotic factors in 12-month-old treated SAMP8 mice with both I2-IR ligands. a A significant increase in PSD95 protein levels in the MCR5 group compared with the other two groups. b A tendency for SYN protein levels to increase in both I2-IR ligand treated groups compared with the Control group. c A tendency for a reduction in the spectrin fragment SPBD 150, and a significant reduction in the spectrin fragment SPBD 120 in the MCR9 group compared with the Control group. d A significant reduction in Caspase-3 protein levels in both I2-IR ligand groups compared with the Control group. e A significant reduction in Bcl-2 protein levels in both I2-IR ligand groups compared with the Control group. f A significant reduction in Bax protein levels in the MCR9 group compared with the other groups. Values in bar graphs are adjusted to 100% for protein level of the Control group. Representative WB for each protein in the mouse hippocampus is shown. Data are expressed as means ± SEM (n=5 animals per group) and analyzed using one-way ANOVA followed by Tukey’s post hoc test for multiple comparisons. *p<0.05, **p<0.001