Fig. 7.
Changes in kinase signaling pathways reduced hyperphosphorylation of Tau in 12-month-old SAMP8 mice treated with both I2-IR ligands. a A significant increase in the p-AKT ratio in the MCR5 group compared with the other two groups. b A significant increase in inactive p-GSK3β (Ser9) protein levels in both I2-IR ligand treated groups compared with the Control group. c A significant reduction in p-ERK½ in both I2-IR ligand treated groups compared with the Control group. d Changes in the p-CDK5/CDK5 ratio induced by MCR5 and MCR9 treatment. e Changes in the p25/p35 ratio in the MCR5 and MCR9 groups compared with the Control group. Representative WB are shown. f A reduction in p-Tau (Ser396), as well as a significant reduction in p-tau (Ser404) in both I2-IR ligand treated groups compared with the Control group. Values in bar graphs are adjusted to 100% for protein level of the Control group. Data are expressed as means ± SEM (n=5 animals per group) and analyzed using one-way ANOVA followed by Tukey’s post hoc test for multiple comparisons. *p<0.05, **p<0.01, ***p<0.001