Fig. 8.
Changes in APP processing and Aβ degradation enzymes in 12-month-old SAMP8 mice treated with both I2-IR ligands. Representative WB of the APP and its fragments. a A significant increase in sAPPα protein levels in the MCR9 group compared with the Control group, and no significant difference between the MCR5 and Control groups. b A significant reduction in sAPPβ protein levels in the MCR5 group compared with the Control group, and no significant difference between the MCR9 and Control groups. c A significant increase in Adam10 gene expression in the MCR5 group compared with the Control group, and no significant difference in the MCR9 group. d A significant increase in NEP gene expression in the MCR5 group compared with the Control group, and no significant difference in the MCR9 group. Values in bar graphs were adjusted to 100% for protein level of the Control group. Gene expression levels were determined by real-time PCR. Data are expressed as means ± SEM (n=4-5 animals per group) and analyzed using one-way ANOVA followed by Tukey’s post hoc test for multiple comparisons. *p<0.05