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. 2019 Jun 6;9:8324. doi: 10.1038/s41598-019-43552-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Classification of antibodies. Three representative examples are shown for each of the enrichment categories (ON-target, CO-target, OFF-target, and NO-target). On the top of each plot are the target gene, antibody ID and the number of replicated IP performed for the antibody. The dots in each plot represent protein identifications made in all the replicates available for the specific antibody. Green dots: z-score >5 and LFQ intensity >1e + 07; yellow dots: z-score > 3 and LFQ intensity >1e + 07; red dots: z-score > 3 and LFQ intensity <1e + 07. Text: expected target and hypothesized off-targets or interactors. A complete list of identified protein and relative z-scores are available in Supplementary Excel Table (Sheet: z-score > 2.5). (B) Paired antibodies and co-enrichment profiles. The z-score/LFQ intensity plots of paired antibodies raised against IGFBP2 are shown for HPA004754, HPA045140, HPA077723. (H+) refers to heat treated plasma and (H−) to untreated plasma. IGF2 was identified as P01344, and P01344-2 (*).