Table 4.
Interactions among genes with higher CG contents in relation to asthma diagnosed at 6 years of age in MDR analyses.
| Rank* | Gene-gene interaction | Balanced accuracy (%) # | p § | |
|---|---|---|---|---|
| 1) Two-way interactions | ||||
| 1 | LMO2_P794 | LMO2_E148 | 0.5788 | 0.2517 |
| 2 | LMO2_P794 | IL10_P325 | 0.5636 | 0.0577 |
| 3 | LMO2_794 | GSTM1_P266 | 0.5584 | 0.0207 |
| 4 | LMO2_E148 | IL10_P325 | 0.5828 | 0.0059 |
| 5 | LMO2_E148 | GSTM1_P266 | 0.5778 | 0.0207 |
| 6 | IL10_P325 | GSTM1_P266 | 0.5550 | 0.0577 |
| 2) Three-way interaction | ||||
| 1 | LMO2_P794 LMO2_E148 IL10_P325 | 0.5928 | 0.0059 | |
| 2 | LMO2_P794 LMO2_E148 GSTM1_P266 | 0.5820 | 0.0577 | |
| 3 | LMO2_E148 IL10_P325 GSTM1_P266 | 0.5834 | 0.0059 | |
| 4 | LMO2_P794 IL10_P325 GSTM1_P266 | 0.5657 | 0.2517 | |
*
The ranking was determined from the ratio of correct classifications to the total number of instances classified within the training dataset according to the function of track top models.
#
The balanced accuracy was calculated across all cross-validation intervals as (Sensitivity + Specificity)/2.
§
The classification of high- and low-risk groups in two- or three-way-mode MDR analyses was validated through Chi-squared tests using the dataset from 361 subjects.