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. 2019 May 31;12:144. doi: 10.3389/fnmol.2019.00144

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Copyright © 2019 Welch, Forster, Atlas and Baro.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transiently transfecting HEK cells with Kv4.2g K579R significantly decreases I_A G_max compared to control. (A–C) Representative current traces for each treatment group. (D) Plots showing I_A G_max. Each data point represents one cell, and data for each treatment group were pooled from ≥3 independent transfections. Orange asterisks, significant differences in I_A G_max among HEK cells expressing Kv4.2g, Kv4.2g K437R, and Kv4.2g K579R. One-way ANOVA with Tukey’s post hoc, F_(2,35) = 9.75, p = 0.0004. Blue asterisks, significant differences in I_A when SUMO+Ubc9 was co-transfected. Kv4.2g: control, 54.2 nS ± 7.9; SUMO+Ubc9, 27.8 nS ± 5.2; t-test p = 0.014. Kv4.2g K437R: control, 62.1 nS ± 5.9; SUMO+Ubc9, 46.9 nS ± 5.9; t-test p = 0.049. Kv4.2g K579R: control, 27.6 nS ± 3.59; SUMO+Ubc9, 36.2 nS ± 4.84; t-test p = 0.18.