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. 2019 May 31;12:144. doi: 10.3389/fnmol.2019.00144

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Copyright © 2019 Welch, Forster, Atlas and Baro.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The ability to manipulate Kv4.2 channel SUMOylation is lost when K437 and K579 are mutated to R. (A,C,E) Representative experiments using the indicated stable mutant cell line. (B,D,F) Bar graphs showing normalized fraction of SUMOylated Kv4.2 channels. Each data point represents one independent experiment. All data points were normalized by the mean value for the mCherry treatment group. N/S indicates not significant. Kv4.2g K437R+K579R: control, 1.0 ± 0.13; SUMO+Ubc9, 0.98 ± 0.11; t-test p = 0.90. Kv4.2g K437R: control, 1.0 ± 0.088; SUMO+Ubc9, 1.3 ± 0.15; t-test p = 0.11. Kv4.2g K579R: control, 1.0 ± 0.16; SUMO+Ubc9, 1.3 ± 0.31; t-test p = 0.51.